Houston, TX · Gulf Freeway · 20 Years of Clinical Practice

Medical weight loss, physician-prescribed.

Houston's dedicated GLP-1 clinic — where semaglutide, tirzepatide, and hormone therapy are written, titrated, and monitored by Dr. Joseph Sleiman MD. No wellness influencers. No one-size protocols. Real medicine.

Schedule your consultation View all services
Medical Director Joseph E. Sleiman, MD
Experience 20 years in clinical practice
Appointments 713 · 999 · 5161
Physician consultation at Clinic 45, Houston TX
Houston45Clinic
20+
Years clinical practice
6
Weight-loss disciplines
1
Dedicated physician
77017
Houston, TX
Physician consultation at Clinic 45 Houston
// 01 · The premise

Semaglutide is a tool. The physician is the protocol.

GLP-1 medications are the most significant advance in weight management in a generation — but only when prescribed correctly. At Clinic 45, Dr. Sleiman evaluates every patient's metabolic baseline, cardiovascular history, and lifestyle before any prescription is written. The titration schedule is yours, not a template.

In 2026, the semaglutide market has become a retail product. Telehealth apps dispense it in three clicks with no labs, no follow-up, and no accountability. Clinic 45 is the alternative: in-person, physician-led, with monthly monitoring that catches what apps can't see.

About Dr. Sleiman
// 02 · Services

Six disciplines, one physician.

Every service at Clinic 45 is physician-supervised. That means a real exam, a real conversation, and a plan that evolves as you do — not a standing order renewed sight-unseen every 90 days.

No. 01

Semaglutide

Weekly GLP-1 receptor agonist injection. Physician-titrated from 0.25 mg upward — appetite regulation, blood sugar stability, and meaningful weight loss without crash dieting.

Read brief
No. 02

Tirzepatide

Dual GLP-1/GIP receptor agonist — the most effective FDA-approved weight loss medication available. Clinical trials showed up to 22.5% body weight reduction. Prescribed only after full evaluation.

Read brief
No. 03

Medical Weight Loss

Comprehensive program: metabolic panel, body composition analysis, nutritional review, and a tailored roadmap. For patients who want the full picture — not just a prescription.

Read brief
No. 04

B12 Injections

Methylcobalamin B12 administered intramuscularly — supports energy metabolism, neurological function, and the fatigue that often accompanies caloric restriction during weight loss.

Read brief
No. 05

IV Hydration Therapy

Clinical-grade infusions — hydration, electrolytes, vitamin complexes, and NAD+ options. Administered in a supervised clinic setting, not a pop-up wellness bar.

Read brief
No. 06

Hormone Therapy

TRT for men, estrogen/progesterone HRT for women — labs-driven, physician-monitored, and adjusted quarterly. Hormonal imbalance is often the hidden barrier to sustainable weight loss.

Read brief
// 03 · The difference

The $1B market sells convenience. We sell results with accountability.

Semaglutide crossed $1 billion in US prescriptions in 2024. The problem isn't the medication — it's the model. Most patients are getting it from apps, compounding pharmacies, and med spas where no one is watching their blood pressure, their thyroid, or their muscle mass as the weight comes off.

Dr. Sleiman has practised clinical medicine for 20 years. He has seen what happens when GLP-1s are managed well — and what happens when they are not. Clinic 45 exists to be the place Houston patients can point to and say: that's where the medicine actually happened.

Dr. Sleiman's approach
Physician-led weight loss care at Clinic 45
// 04 · The physician

Dr. Joseph Sleiman, MD.

20 years of clinical practice in Houston. The protocol you receive at Clinic 45 is designed and monitored by a physician who reads your labs and knows your history — not an algorithm.

Full biography
Dr. Joseph E. Sleiman MD, Clinic 45 Houston
Dr. Joseph E. Sleiman · MD · 20 Years Clinical Practice
Medical Director · MD

Joseph E. Sleiman

Dr. Sleiman has spent 20 years practising medicine in Houston. At Clinic 45, he directs every weight loss and hormone protocol personally — reviewing labs, adjusting dosages, and keeping a close patient relationship through the entire arc of treatment.

He is reachable directly. Patients do not see a different provider at each visit. That is not a differentiator here — it is the minimum standard.

★★★★★
5.0
Google · Houston, TX
Schedule a consult
// What patients say

Actually monitored.

Patients consistently note that Dr. Sleiman reviews their labs personally and adjusts the plan — a sharp contrast to telehealth providers who auto-renew prescriptions without a conversation.

No upselling, no pressure.

The practice runs on clinical outcomes, not retail. Patients report being told honestly when a medication is not right for them — and being given alternatives without pressure to spend more.

The weight stayed off.

The metric that matters: patients who complete a full Clinic 45 program report sustained results, because the protocol was built around them specifically — not the average patient in a clinical trial.

Novo Nordisk — Ozempic® & Wegovy® partner practice Eli Lilly — Zepbound® & Mounjaro® authorized Physician-led · In-person monitoring Lab-driven hormone protocols No compounding pharmacy shortcuts
// 05 · Programs

Structured programs, not standing orders.

Clinic 45 offers three program tiers — all physician-supervised, all include labs and monitoring. Choose the depth of engagement that fits your timeline and goals.

Starter Initial consult + labs + first month of medication management
Quarterly 3-month program with monthly check-ins and dosage titration
Annual Full-year commitment with hormone panel, IV lounge access, and priority scheduling
Ask pricing
FIRST CONSULT · NO OBLIGATION
View all programs
// 06 · Visit

Gulf Freeway, Houston.

First consultations are unhurried. Bring any recent labs, your medication history, and a clear picture of what you want to achieve. Dr. Sleiman will tell you honestly whether Clinic 45 is the right fit.

Address 8221 Gulf Fwy, Suite 400Houston, Texas 77017
Hours Mon · Tue · Wed · Thu9:00 AM — 5:00 PM
Friday9:00 AM — 3:00 PM
Sat · SunClosed
Appointments 713 · 999 · 5161appointments@clinic45.com
Social Instagram: @clinic.45 · Facebook: clinic.45
Houston · Gulf Freeway · Suite 400

Ready to stop guessing and start losing?

The first consultation is the most important one. Dr. Sleiman will review your history, run the right labs, and tell you exactly what's possible — and what's not. No glossy promises. Real medicine.

Book your consultation Call 713 · 999 · 5161